Weekly Update: Major Startup Funding Rounds in the U.S. (March 15-21, 2025)

This week, our focus is on the most significant investment rounds over $100 million in U.S.-based startups. While funding activity has slowed for the second consecutive week, one standout round reached an impressive $500 million, indicating continued interest in transformative companies.

Top Funding Rounds of the Week

1. Nerdio: $500M in Information Technology

   Chicago’s Nerdio, a company that streamlines IT operations through automation, secured a $500 million equity round led by General Atlantic, raising its valuation to $1.2 billion. With over 15,000 clients spread across 50 countries, Nerdio is proving its ability to generate consistent growth, reporting an annual recurring revenue increase of over 85%. Founded in 1998, it has now raised a total of $625 million, according to data from Crunchbase.

2. Latigo Biotherapeutics: $150M in Biotech

   Addressing the ongoing challenge of opioid dependency, Thousand Oaks, California’s Latigo Biotherapeutics completed a $150 million Series B funding round led by Blue Owl. The company is pioneering non-opioid pain relief options through clinical-stage developments, specifically targeting pain at its source with Nav1.8 inhibitors. Established in 2018, Latigo has accumulated $300 million in funding to date.

3. BuildOps: $127M in Commercial Contracting

   BuildOps, based in Santa Monica, is modernizing the contracting industry with its software solutions designed for a $300 billion market. The platform assists various skilled trades with project management from construction to maintenance, raising $127 million this week, led by Meritech Capital Partners. Since its founding in 2018, BuildOps has garnered over $225 million in investments.

4. Curevo: $110M in Biotech

   In a significant boost for vaccine development, Seattle’s Curevo raised $110 million in Series B financing, headed by new investor Medicxi. The funds aim to advance the company’s vaccine for shingles, which can lead to severe nerve pain in 10% to 18% of affected individuals. Founded in 2018, Curevo has successfully raised a total of $196 million.

5. Dataminr: $85M in Analytics

   New York’s Dataminr, specializing in real-time data analytics, received $85 million in funding from HSBC and NightDragon. The company aims to expand its capabilities in detecting significant events from public data signals. Founded in 2009, Dataminr has raised $1.1 billion over its lifetime.

6. Arbor Biotechnologies: $74M in Biotech

   With a focus on genetic health solutions, Arbor Biotechnologies, based in Cambridge, Massachusetts, secured $74 million in new funding as part of its Series C round, led by Arch Venture Partners. The firm has raised nearly $305 million since its inception in 2016.

7. Ampersand Biomedicines: $65M in Biotech

   Boston’s Ampersand Biomedicines raised $65 million in its Series B round to facilitate targeted medication development, attracting investments from well-known firms such as Flagship Pioneering and Eli Lilly. Since its founding in 2021, the company has raised a total of $115 million.

8. Carbon Arc: $56M in Information Technology

   New York-based Carbon Arc announced a successful $56 million fundraising round, led by Liberty City Ventures, focusing on structured, model-ready data solutions for clients.

9. Cardiac Dimensions: $53M in Medical Devices

   Cardiac Dimensions of Kirkland, Washington, raised $53 million in Series E funding to support their minimally invasive heart device aimed at patients with functional mitral regurgitation. The capital will fund international growth and trials across the U.S. The company has raised nearly $263 million since its founding.

10. Graphite: $52M in Developer Tools

    Graphite in New York, known for its code review dashboard, raised $52 million in Series B funding, led by Accel, bringing its total raised to $72 million since its inception in 2020.

Highlighted Global Deal

Beyond the U.S., the notable funding round was completed by Maxion Therapeutics, a U.K.-based biotech firm that raised approximately $75 million in its Series A funding.

Methodology

This report compiles data from Crunchbase on the largest announced funding rounds raised by U.S.-based companies for the week spanning March 15 to March 21, 2025. While we strive for comprehensiveness, some rounds may experience delays in reporting.

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