Major Startup Funding Rounds in 2025: $100 Million Plus Deals
As the venture capital landscape continues to evolve, tracking significant funding rounds can offer critical insights into industry trends and areas of growth. In this Weekly Roundup, we present the most substantial funding deals exceeding $100 million closed by U.S.-based companies between April 12 and April 18, 2025.
Overview of Recent Endeavors
This past week witnessed a flourishing investment environment, especially within the realms of artificial intelligence, energy, blockchain, and biotech. Notably, several startups achieved remarkable funding milestones, highlighting the diverse interests of investors.
Top Funding Rounds of the Week
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Safe Superintelligence – $2 Billion
This artificial intelligence research lab, co-founded by former OpenAI chief scientist Ilya Sutskever, secured an impressive $2 billion in funding at a valuation of $32 billion. The round was spearheaded by Greenoaks Capital Partners and follows a previous $1 billion investment raised within just seven months.
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Mainspring Energy – $258 Million
California-based Mainspring Energy, known for its innovative generators tailored for the energy sector, closed a $258 million Series F round led by General Catalyst. The company’s focus on energy-efficient solutions is gaining traction as demand surges, particularly in data centers.
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Auradine – $153 Million
Auradine, located in Santa Clara, California, raised $153 million in a Series C round, focusing on sustainable Bitcoin mining and AI-driven data center networks, led by StepStone Group. This startup has surpassed $300 million in total funding since its inception in 2022.
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Glycomine – $115 Million
Glycomine, a biotech firm from San Carlos, California, announced a $115 million Series C round, led by prominent investors such as Abrdn and Advent Life Sciences. This funding will support the advancement of therapies for orphan diseases as they prepare for phase 2b clinical trials.
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Science – $104 Million
This healthcare startup, founded by a former Neuralink co-founder, raised $104 million to develop brain and retina implant systems for healthcare applications. The round was significantly backed by Khosla Ventures, bringing its total funding to $177 million since its launch in 2021.
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Hammerspace – $100 Million
San Mateo’s Hammerspace, a data platform for AI applications, secured $100 million led by Altimeter Capital. Since its founding in 2018, Hammerspace has garnered nearly $157 million in total funding.
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Attovia Therapeutics – $90 Million
Newly founded in 2023, Attovia Therapeutics, dedicated to developing biotherapeutics for immune-mediated diseases, completed a $90 million Series C round led by Deep Track Capital.
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Chapter – $75 Million
This New York-based startup and Medicare navigation platform raised $75 million in a Series D funding round led by Stripes, enhancing its resources to assist seniors in finding appropriate coverage.
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Exaforce – $75 Million
In its Series A funding round, Exaforce, located in San Jose, California, raised $75 million to develop AI-integrated security solutions for operational centers, backed by Khosla Ventures and Mayfield Fund.
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Luma Financial Technologies – $63 Million
Cincinnati’s Luma Financial Technologies, a fintech platform aimed at serving banks and brokers, closed a $63 million Series C round led by Sixth Street, amassing a total of $93 million.
Global Spotlight
Beyond U.S. borders, Beijing-based Zelos made headlines by securing $200 million in a Series B round for its AI-driven contributions to the autonomous driving sector, underscoring the growing international investment interest in technology startups.
These funding rounds reflect the vibrant investment climate aimed at innovative solutions across various sectors. For ongoing updates regarding prominent funding activities and market shifts, refer to Crunchbase.
